Atogepant: The One that Got Migraines Away!

Atogepant: The One that Got Migraines Away!

Atogepant, sold under the brand name Qulipta, is a migraine preventative pill that is taken daily.

How does atogepant work?

Atogepant works on blocking calcitonin gene-related peptide from attaching to its receptors. CGRP has been shown to increase in migraine attacks. By blocking CGRP from its receptors, it can prevent the increase of serum CGRP. This, in turn, can prevent a migraine.

Why are migraines so debilitating?

Migraines can affect people in different ways. Some of the more common effects of migraines are:

  • The ability to focus
  • Changes in vision
  • Physical movement
  • Balance
  • Perception of pain
  • The overall quality of life


There are thought to be four phases of migraines. These phases are:

  • Prodrome
    • This phase may last hours to days.
    • This phase includes symptoms such as mood swings or tiredness.
  • Aura
    • This phase may last from 5 to 60 minutes
    • Around 33% of people who suffer with migraines may experience this phase.
    • An aura affects vision by visual disturbances such as flashers, floaters, or bright lights. Temporary vision loss may also be present.
  • Headache phase
    • This phase may last from 4 to 72 hours
    • This is when the pain in the head occurs.
    • It may cause light or sound sensitivity, nausea, or vomiting.
  • Postdrome
    • This phase may last 24 to 48 hours
    • It may be described as a migraine hangover. 
    • People may feel tired or achy.

What are the possible side effects of atogepant?

With all drugs, there is a possibility of side effect. The most common side effects reported with atogepant are:

  • Nausea
  • Constipation
  • Fatigue/sleepiness

Is this medication safe if you are pregnant or breastfeeding?

It is not known if atogepant can harm an unborn baby. It is also unknown if the medication is transmitted to the baby through breast milk. Contact your medical provider for the best recommendations.

This article has been written by Umedoc staff and fully reviewed and liked by Jim Liu, MD.

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